Biliary secretion and enterohepatic recycling of fenbendazole metabolites in sheep.

@article{Hennessy1993BiliarySA,
  title={Biliary secretion and enterohepatic recycling of fenbendazole metabolites in sheep.},
  author={D. R. Hennessy and J. W. Steel and Roger K. Prichard},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1993},
  volume={16 2},
  pages={
          132-40
        }
}
Fenbendazole (FBZ) was administered intraruminally at 5.0 mg/kg, containing a trace of [14C]-FBZ, to sheep fitted with a permanent bile duct cannula and the behaviour of FBZ and its metabolites examined in bile and plasma. Of the administered radiolabelled dose, 47% was secreted in bile of which 34% was accounted for as conjugated and 4% as unconjugated (free) metabolites. Hydroxylated oxfendazole (OH.OFZ) was the major biliary metabolite contributing 66%, and hydroxy-FBZ (OH.FBZ) 27%, of the… CONTINUE READING

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