Biliary intervention aggravates cholestatic liver injury, and induces hepatic inflammation, proliferation and fibrogenesis in BDL mice.

@article{Wen2011BiliaryIA,
  title={Biliary intervention aggravates cholestatic liver injury, and induces hepatic inflammation, proliferation and fibrogenesis in BDL mice.},
  author={Yang-an Wen and Ding Liu and Qian-Yun Zhou and Shi-feng Huang and Peng Luo and Yu Xiang and Shan Sun and Dan Luo and Yu-fang Dong and Li-Ping Zhang},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2011},
  volume={63 3},
  pages={277-84}
}
Obstructive cholestasis occurs in various clinical situations, whose pathological process is complex and not well known. The present study was initiated to display the complex and multifaceted pathological process caused by obstructive cholestasis in bile duct-ligated mice. Adult mice were bile-duct-ligated or sham-operated, and serum and liver tissues were collected at the indicated time points. Automatic biochemical analyzer was used to monitor serum biochemical index; TUNEL, HE staining… CONTINUE READING
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