Biliary excretion of phenolphthalein sulfate in rats.

@article{Tanaka2003BiliaryEO,
  title={Biliary excretion of phenolphthalein sulfate in rats.},
  author={Hiroyuki Tanaka and Naoyo Sano and Hajime Takikawa},
  journal={Pharmacology},
  year={2003},
  volume={68 4},
  pages={177-82}
}
Glucuronide and glutathione conjugates have been reported to be substrates of multidrug resistance protein 2 (Mrp2), whereas sulfates of nonbile acid organic anions have never been reported as substrates of Mrp2. To further examine the substrate specificity of Mrp2, we examined the effects of bile acid sulfates on the biliary excretion of phenolphthalein sulfate in rats. The biliary excretion of phenolphthalein sulfate was markedly delayed in Eisai hyperbilirubinemic rats, an Mrp2-deficient… CONTINUE READING

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