Biliary excretion of barbiturates.

Abstract

1. Pentobarbitone and phenobarbitone are excreted into the bile of rats.2. The concentration of pentobarbitone and/or its metabolites in the bile is 22-fold higher than in the plasma; the concentration of phenobarbitone and/or its metabolites in bile is 10-fold higher than in the plasma.3. Probenecid decreases the excretion of the barbiturates into the bile… (More)

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