Biliary excretion of amoxycillin and ceftriaxone after intravenous administration in man.

@article{Maudgal1982BiliaryEO,
  title={Biliary excretion of amoxycillin and ceftriaxone after intravenous administration in man.},
  author={Dr D. P. Maudgal and J Douglas Maxwell and L. J. Lees and R N Wild},
  journal={British journal of clinical pharmacology},
  year={1982},
  volume={14 2},
  pages={213-7}
}
1 Plasma and biliary concentrations of amoxycillin and ceftriaxone were measured after bolus intravenous administration (500 mg) in four subjects with normal hepato-biliary and renal function. 2 The mean plasma elimination half-life for ceftriaxone (t 1/2 = 330 +/- 30 min) was considerably longer than that for amoxycillin (t 1/2 = 60 +/- 9 min). 3 The biliary concentration of ceftriaxone was above plasma concentration of the drug throughout the study period, whereas amoxycillin concentration in… CONTINUE READING

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