Biliary excretion and enterohepatic cycling of glycyrrhizin in rats.

@article{Ichikawa1986BiliaryEA,
  title={Biliary excretion and enterohepatic cycling of glycyrrhizin in rats.},
  author={Tomotake Ichikawa and S Ishida and Y Sakiya and Yasufumi Sawada and Manabu Hanano},
  journal={Journal of pharmaceutical sciences},
  year={1986},
  volume={75 7},
  pages={672-5}
}
The enterohepatic cycling of glycyrrhizin was examined using rats with and without biliary fistulization. The plasma decay in the control rats without fistulization following an iv dose of 100 mg/kg of glycyrrhizin, was generally biphasic. However, secondary peaks were observed in all rats in the elimination phase, i.e., 0.5 to 12 h following dosing. The plasma concentrations in the rats with biliary fistulization administered the same dose showed a biexponential decline. The AUC and CLtot were… CONTINUE READING