Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat.

@article{Oh2009BiliaryCO,
  title={Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat.},
  author={Ju-Hee Oh and Se-Eun Park and Chang-koo Shim and Young-Joo Lee},
  journal={Biopharmaceutics & drug disposition},
  year={2009},
  volume={30 2},
  pages={94-8}
}
The aim of this study was to investigate the effect of anesthesia on the pharmacokinetics of bromosulfophthalein (BSP) with focus on biliary clearance. The plasma concentration profile and biliary clearance of intravenously administered BSP was compared in conscious freely moving bile duct catheterized rats and rats anesthetized with ketamine or Zoletil. The plasma concentration of BSP in conscious rats was similar to that of anesthetized rats, irrespective of the anesthetic used. There was no… CONTINUE READING

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