Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.

@article{Wittenburg2002BiliaryCS,
  title={Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.},
  author={Henning Wittenburg and Martin C. Carey},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 5},
  pages={605-9}
}
The long wait for a cellular and functional definition of canalicular transporters for biliary cholesterol appears to be over. Articles in this issue of the JCI provide a fascinating account of the cellular itinerary of two murine ATP-binding cassette (ABC) halftransporters from the ribosome to the hepatocyte apical membranes (1) and show that the corresponding human genes, when overexpressed in transgenic mice, can greatly augment cholesterol secretion into bile (2). This field was opened with… CONTINUE READING

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