Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.

  title={Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.},
  author={Henning Wittenburg and Martin C. Carey},
  journal={The Journal of clinical investigation},
  volume={110 5},
The long wait for a cellular and functional definition of canalicular transporters for biliary cholesterol appears to be over. Articles in this issue of the JCI provide a fascinating account of the cellular itinerary of two murine ATP-binding cassette (ABC) halftransporters from the ribosome to the hepatocyte apical membranes (1) and show that the corresponding human genes, when overexpressed in transgenic mice, can greatly augment cholesterol secretion into bile (2). This field was opened with… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 24 references

Mapping cholesterol gallstone susceptibility (Lith) genes in inbred mice.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver • 2003

New cholesterol gallstone susceptibility (Lith) loci with attractive positional candidate genes in an intercross of PERA/Ei and I/LnJ strains of mice

H. Wittenburg, M. A. Lyons, R. Li, M. C. Carey, B. Paigen
Gastroenterology. 122:A543 • 2002

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

Lee, M.H
Nat . Genet . • 2001

Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol

I. Björkhem, K. Boberg, E. Leitersdorf
The Metabolic and Molecular Basis of Inherited Diseases . • 2001

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