Biliary Innate Immunity: Function and Modulation

  title={Biliary Innate Immunity: Function and Modulation},
  author={Kenichi Harada and Yasuni Nakanuma},
  booktitle={Mediators of inflammation},
Biliary innate immunity is involved in the pathogenesis of cholangiopathies in patients with primary biliary cirrhosis (PBC) and biliary atresia. Biliary epithelial cells possess an innate immune system consisting of the Toll-like receptor (TLR) family and recognize pathogen-associated molecular patterns (PAMPs). Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to maintain homeostasis in the biliary tree, but tolerance to double-stranded RNA (dsRNA) is not found. In… CONTINUE READING


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