Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium.

Abstract

BACKGROUNDS & AIMS Under normal conditions, the biliary tract is a microbial-free environment. The absence of microorganisms has been attributed to various defense mechanisms that include the physicochemical and signaling actions of bile salts. Here, we hypothesized that bile salts may stimulate the expression of a major antimicrobial peptide, cathelicidin… (More)
DOI: 10.1053/j.gastro.2008.12.040
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