Bile salt regulation of fatty acid absorption and esterification in rat everted jejunal sacs in vitro and into thoracic duct lymph in vivo.

@article{Clark1969BileSR,
  title={Bile salt regulation of fatty acid absorption and esterification in rat everted jejunal sacs in vitro and into thoracic duct lymph in vivo.},
  author={M. L. Clark and Henry C. Lanz and John R. Senior},
  journal={The Journal of clinical investigation},
  year={1969},
  volume={48 9},
  pages={
          1587-99
        }
}
This study was performed to investigate whether the malabsorption of fat in the blind loop syndrome is due to the presence of free bile acids or to a deficiency of conjugated bile salts produced by bacterial degradation of normal bile salts, as well as to learn something of the mechanisms by which bile salts might regulate fat absorption. In the everted gut sac of the rat in vitro, conjugated bile salts were necessary for maximal rates of fatty acid esterification to triglycerides, whereas free… 
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Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.
TLDR
Close linear relationships existed between net water movement and fractional absorption of glucose, xylose, and fatty acids, as well as between the absorption rates of these solutes, and net fluid secretion induced by hypertonic D-mannitol had no effect on solute absorption.
Effects of bile diversion on the lipid-reesterifying capacity of the rat small bowel.
Differences in the intestinal absorption of saturated and unsaturated long chain fatty acids.
Intraluminal Precipitation of Bile Acids in Stagnant Loop Syndrome
TLDR
It is suggested that precipitation of unconjugated bile acids, rather than passive absorption, leads to a reduced postprandial concentration of bile acid in the micellar phase of jejunal content, and this is consistent with the hypothesis that fat malabsorption in the stagnant loop syndrome results from decreased mousellar dispersion of lipolytic products.
Perfusion of the hamster jejunum with conjugated and unconjugated bile acids: inhibition of water absorption and effects on morphology.
Vitamin D-3 intestinal absorption in vivo: influence of fatty acids, bile salts, and perfusate pH on absorption.
TLDR
The experiments indicate that vitamin D-3 absorption in vivo is mediated by passive diffusion, and the rate of absorption of the vitamin is influenced by the composition of the perfusate and the thickness of the unstirred layer.
Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects.
Fat absorption after infusing bile salts into the human small intestine.
The intestinal uptake and esterification, in vitro, of fatty acid as a diffusion limited process.
Studies on the effects of unconjugated dihydroxy bile salts on rat small intestinal function in vivo.
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References

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TLDR
Evidence is presented for the concept that conjugated bile salts directly stimulate glyceride metabolism in the intestinal and on factors influencing the uptake and esterification of palmitate-1-C4 and the incorporation of label into lipid from C14glucose.
THE EFFECT OF BILE SALTS ON THE LYMPHATIC ABSORPTION BY THE UNANAESTHETIZED RAT OF INTRADUODENALLY INFUSED LIPIDS.
  • R. G. Morgan
  • Chemistry, Medicine
    Quarterly journal of experimental physiology and cognate medical sciences
  • 1964
TLDR
Results do not support a defect in epithelial re-esterification of fatty acids in the absence of bile, and emulsified oleic acid was as well absorbed in bile fistula animals as in controls and the return or removal of taurocholate did not affect the output of esterified fat in the lymph.
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TLDR
It was concluded that absorption of fatty acid could proceed efficiently in the virtual absence of micellar solubilization, and comparison of the increased output of esterified fat in the lymph with the output of labeled fat suggested that fat absorption did not greatly affect the turnover of endogenous, unlabeled fat.
Bile-salt deconjugation and steatorrhoea in patients with the stagnant-loop syndrome.
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TLDR
Strains of Escherichia coli, Proteus vulgaris, and Streptococcus faecalis were adapted by serial transfer in cholate-containing media to grow more rapidly in high concentrations of cholate and to alter the composition of the cholate more rapidly than unadapted cultures.
The role of altered bile acid metabolism in the steatorrhea of experimental blind loop.
TLDR
Two experimental findings suggest that this alteration of bile acid metabolism plays a role in blind loop steatorrhea, a probable step in fat absorption that occurs optimally in the presence of conjugated bile.
Degradation of bile salts by human intestinal bacteria.
TLDR
A much greater number of strains of bacteria and a wider range of species are tested for the ability to deconjugate bile salts (the first step in bile degradation) and also for their ability to carry out a further step in the degradation, the removal of the 7-hydroxyl group from free cholic acid.
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TLDR
In a variety of diseases involving the intestine, malabsorption has been attributed to the proliferation of bacteria in the small intestine and therapy directed against the organisms has reversed the mal absorption, and attention has focused attention on alterations in bile-salt metabolism in these patients.
Techniques for the collection of lymph from the liver, small intestine, or thoracic duct of the rat.
T HE following techniques for collection of lymph in the rat have been very satisfactory for periods of two or three days for lymph from the liver and for periods up to ten days for lymph from the…
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