Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent.

@article{Chamulitrat2009BileSC,
  title={Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent.},
  author={Wale{\'e} Chamulitrat and Juergen Burhenne and Tobias Rehlen and Anita Pathil and Wolfgang Stremmel},
  journal={Hepatology},
  year={2009},
  volume={50 1},
  pages={143-54}
}
UNLABELLED A decrease of hepatocellular phosphatidylcholine (PC) is associated with hepatic injury, e.g., in nonalcoholic steatohepatitis (NASH). Therefore, we evaluated the hepatoprotective effect of a PC-precursor lipid specifically targeted to the liver. We synthesized the bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE), which was designed to target PC to hepatocytes by way of bile-acid transport systems. We synthesized a fluorescently labeled… CONTINUE READING

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