Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C.

@article{Jones1997BileSA,
  title={Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C.},
  author={Blake A. Jones and Yi Ping Rao and Richard Todd Stravitz and Gregory James Gores},
  journal={The American journal of physiology},
  year={1997},
  volume={272 5 Pt 1},
  pages={
          G1109-15
        }
}
Toxic bile salts induce hepatocyte apoptosis, a model relevant to liver injury during cholestasis. However, the signaling mechanisms culminating in bile salt-induced apoptosis remain unclear. Because protein kinase C (PKC) is activated by bile salts in hepatocytes and causes apoptosis in other cells, we tested the hypothesis that bile salt-induced hepatocyte apoptosis is mediated by PKC. The PKC inhibitors chelerythrine and Gö-6976 reduced, whereas a PKC agonist, phorbol 12-myristate 13-acetate… CONTINUE READING
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