Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells

@inproceedings{JaenssonGyllenbck2011BileRI,
  title={Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells},
  author={E Jaensson-Gyllenb{\"a}ck and Knut Kotarsky and Francisco Zapata and Elisabeth Persson and Thomas E Gundersen and Rune Blomhoff and William W. Agace},
  booktitle={Mucosal Immunology},
  year={2011}
}
Small intestinal lamina propria (SI-LP) CD103+ dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103+ DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol… CONTINUE READING