Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis.

@article{Lankisch2011BilePP,
  title={Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis.},
  author={Tim Oliver Lankisch and Jochen Metzger and Ahmed A Negm and Katja Vosskuhl and Eric Schiffer and Justyna Siwy and Tobias J Weism{\"u}ller and Andrea L. S. Schneider and Kathrin Thedieck and Ralf Baumeister and Petra Zuerbig and Eva Maria Weissinger and Michael P. Manns and Harald Mischak and Jochen Wedemeyer},
  journal={Hepatology},
  year={2011},
  volume={53 3},
  pages={875-84}
}
UNLABELLED Early detection of malignant biliary tract diseases, especially cholangiocarcinoma (CC) in patients with primary sclerosing cholangitis (PSC), is very difficult and often comes too late to give the patient a therapeutic benefit. We hypothesize that bile proteomic analysis distinguishes CC from nonmalignant lesions. We used capillary electrophoresis mass spectrometry (CE-MS) to identify disease-specific peptide patterns in patients with choledocholithiasis (n = 16), PSC (n = 18), and… CONTINUE READING

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