Bile mediates intestinal pathology in endotoxemia in rats.

@article{Jackson2000BileMI,
  title={Bile mediates intestinal pathology in endotoxemia in rats.},
  author={Graham D. F. Jackson and Yu-Cheng Dai and William A Sewell},
  journal={Infection and immunity},
  year={2000},
  volume={68 8},
  pages={
          4714-9
        }
}
Intestinal pathology frequently accompanies experimental endotoxic shock and is mediated by proinflammatory cytokines. Our hypotheses are that hepatobiliary factors operating from the luminal side of the gut make a major contribution to this damage and that tumor necrosis factor alpha (TNF-alpha) is involved in the pathology. We treated rats with lipopolysaccharide (LPS) intravenously and found that external drainage of bile totally protected the gastrointestinal tract, macroscopically and… CONTINUE READING
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