Bile ductular damage induced by methylene dianiline inhibits oval cell activation.

@article{Petersen1997BileDD,
  title={Bile ductular damage induced by methylene dianiline inhibits oval cell activation.},
  author={Bryon E. Petersen and Vladim{\'i}r Zajac and George K Michalopoulos},
  journal={The American journal of pathology},
  year={1997},
  volume={151 4},
  pages={905-9}
}
Administration of 2-acetylaminofluorene (2-AAF) given before a two-thirds partial hepatectomy (PHx), results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. Our objective in this study was to examine the oval cell response and associated alpha-fetoprotein (AFP) gene expression by combining 2-AAF with selective hepatic damage caused by either carbon tetrachloride (CCl4) exposure or by PHx. We also examined oval cell response with the above two protocols (2… CONTINUE READING