Bile canalicular dynamics in hepatocyte sandwich cultures

Abstract

Many substances are hepatotoxic due to their ability to cause intrahepatic cholestasis. Therefore, there is a high demand for in vitro systems for the identification of cholestatic properties of new compounds. Primary hepatocytes cultivated in collagen sandwich cultures are known to establish bile canaliculi which enclose secreted biliary components… (More)
DOI: 10.1007/s00204-015-1575-9

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