Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivity.

@article{Shin2012BilebasedDO,
  title={Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivity.},
  author={S M Shin and Kyoungbun Lee and Baek-Hui Kim and N. P. Cho and Jin-Young Jang and Yong-Tae Kim and Donguk Kim and Ja June Jang and Gyeong Hoon Kang},
  journal={The Journal of molecular diagnostics : JMD},
  year={2012},
  volume={14 3},
  pages={256-63}
}
Extrahepatic cholangiocarcinoma (EHC) is usually difficult to diagnose by bile cytology because of cellular disintegration. However, DNA samples from bile fluid can provide sufficient materials to screen for the presence of EHC. We developed DNA methylation marker panels that can be used for MethyLight assay-based detection of EHC in bile fluid specimens. The methylation status of 59 DNA methylation markers was investigated in 20 EHC and 20 non-neoplastic gallbladder tissue samples with… CONTINUE READING

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