Bile acids modulate signaling by functional perturbation of plasma membrane domains.

@article{Zhou2013BileAM,
  title={Bile acids modulate signaling by functional perturbation of plasma membrane domains.},
  author={Yong Zhou and Kelsey N. Maxwell and Erdinc Sezgin and Maryia Lu and Hong Liang and John F Hancock and Elizabeth J. Dial and Lenard M. Lichtenberger and Ilya Levental},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 50},
  pages={35660-70}
}
Eukaryotic cell membranes are organized into functional lipid and protein domains, the most widely studied being membrane rafts. Although rafts have been associated with numerous plasma membrane functions, the mechanisms by which these domains themselves are regulated remain undefined. Bile acids (BAs), whose primary function is the solubilization of dietary lipids for digestion and absorption, can affect cells by interacting directly with membranes. To investigate whether these interactions… CONTINUE READING

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