Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

@article{Torra2003BileAI,
  title={Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.},
  author={In{\'e}s Pineda Torra and Thierry Claudel and Caroline Duval and Vladimir Kosykh and J. -C. Fruchart and Bart Staels},
  journal={Molecular endocrinology},
  year={2003},
  volume={17 2},
  pages={259-72}
}
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls lipid and glucose metabolism and exerts antiinflammatory activities. PPARalpha is also reported to influence bile acid formation and bile composition. Farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor that mediates the effects of bile acids on gene expression and plays a major role in bile acid and possibly also in lipid metabolism. Thus, both PPARalpha and FXR appear to act on… CONTINUE READING
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