Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium‐driven bile uptake

@inproceedings{Ferdek2016BileAI,
  title={Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium‐driven bile uptake},
  author={Pawel E Ferdek and Monika A Jakubowska and Julia V Gerasimenko and Oleg V Gerasimenko and Ole H Petersen},
  booktitle={The Journal of physiology},
  year={2016}
}
KEY POINTS Acute biliary pancreatitis is a sudden and severe condition initiated by bile reflux into the pancreas. Bile acids are known to induce Ca2+ signals and necrosis in isolated pancreatic acinar cells but the effects of bile acids on stellate cells are unexplored. Here we show that cholate and taurocholate elicit more dramatic Ca2+ signals and necrosis in stellate cells compared to the adjacent acinar cells in pancreatic lobules; whereas taurolithocholic acid 3-sulfate primarily affects… CONTINUE READING

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