Bile acids induce glucagon-like peptide 2 secretion with limited effects on intestinal adaptation in early weaned pigs.

@article{Ipharraguerre2013BileAI,
  title={Bile acids induce glucagon-like peptide 2 secretion with limited effects on intestinal adaptation in early weaned pigs.},
  author={Ignacio R Ipharraguerre and Gemma Ted{\'o} and David Menoyo and Nuria de Diego Cabero and Jens Juul Holst and M Nofrarias and Alessandro Mereu and Douglas G Burrin},
  journal={The Journal of nutrition},
  year={2013},
  volume={143 12},
  pages={
          1899-905
        }
}
Early weaning is a stressful event characterized by a transient period of intestinal atrophy that may be mediated by reduced secretion of glucagon-like peptide (GLP) 2. We tested whether enterally fed bile acids or plant sterols could increase nutrient-dependent GLP-2 secretion and improve intestinal adaptation in weanling pigs. During the first 6 d after weaning, piglets were intragastrically infused once daily with either deionized water (control), chenodeoxycholic acid (CDC; 60 mg/kg body… CONTINUE READING
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