Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration.

@article{Voronina2005BileAI,
  title={Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration.},
  author={Svetlana G. Voronina and Olexyi V Gryshchenko and Oleg V Gerasimenko and Anne K. Green and Ole H Petersen and Alexei V Tepikin},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 3},
  pages={1764-70}
}
Biliary disease is a major cause of acute pancreatitis. In this study we investigated the electrophysiological effects of bile acids on pancreatic acinar cells. In perforated patch clamp experiments we found that taurolithocholic acid 3-sulfate depolarized pancreatic acinar cells. At low bile acid concentrations this occurred without rise in the cytosolic calcium concentration. Measurements of the intracellular Na(+) concentration with the fluorescent probe Sodium Green revealed a substantial… CONTINUE READING

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Bile Induces Cationic Current and Intracellular Na Increase 1770 by on F ebuary 7, 2008 w w w .jb.org D ow nladed fom

S. G. Voronina, S. L. Barrow, O. V. Gerasimenko, O. H. Petersen, A. V. Tepikin
J. Biol. Chem. 279, • 2004

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