Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.

@article{Gerasimenko2006BileAI,
  title={Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.},
  author={Julia V Gerasimenko and Sarah E. Flowerdew and Svetlana G. Voronina and Tatiana Sukhomlin and Alexei V Tepikin and Ole H Petersen and Oleg V Gerasimenko},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 52},
  pages={40154-63}
}
Gallstones can cause acute pancreatitis, an often fatal disease in which the pancreas digests itself. This is probably because of biliary reflux into the pancreatic duct and subsequent bile acid action on the acinar cells. Because Ca(2+) toxicity is important for the cellular damage in pancreatitis, we have studied the mechanisms by which the bile acid taurolithocholic acid 3-sulfate (TLC-S) liberates Ca(2+). Using two-photon plasma membrane permeabilization and measurement of [Ca(2+)] inside… CONTINUE READING
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