Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis.

@article{Matsuzaki2013BileAI,
  title={Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis.},
  author={Juntaro Matsuzaki and Hidekazu Suzuki and Hitoshi Tsugawa and Mitsuhiro Watanabe and Sharif M. Hossain and Eri Arai and Yoshimasa Saito and Shigeki Sekine and Toshihiro Akaike and Yae Kanai and Ken-ichi Mukaisho and Johan Auwerx and Toshifumi Hibi},
  journal={Gastroenterology},
  year={2013},
  volume={145 6},
  pages={1300-11}
}
BACKGROUND & AIMS Bile reflux contributes to development of Barrett's esophagus (BE) and could be involved in its progression to esophageal adenocarcinoma (EAC). We investigated whether bile acids affect levels or functions of microRNAs (MIRs) 221 and 222, which bind to the 3'-UTR of p27Kip1 messenger RNA to inhibit its translation. Reduced p27Kip1 increases degradation of the transcription factor CDX2; levels of CDX2 have been reported to decrease during progression of BE to EAC. METHODS We… CONTINUE READING
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Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa

Journal of Gastroenterology • 2003
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