Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism.

@article{Thomas2008BileAA,
  title={Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism.},
  author={Charles Thomas and Johan Auwerx and Kristina Schoonjans},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2008},
  volume={18 2},
  pages={167-74}
}
A multitude of endocrine, neural, and metabolic signaling pathways are activated upon food intake to coordinate the effective use of the available energy. Bile acids (BAs) are released from the gallbladder after each meal and subsequently facilitate the digestion of nutrients. Since concentrations of BAs increase postprandially in the serum, they are also signals of food availability that bridge nutrition with metabolism. Both nuclear and membrane receptors mediate BA signaling. Whereas the… CONTINUE READING
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