Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae.

@article{Koestler2014BileAA,
  title={Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae.},
  author={Benjamin J Koestler and Christopher M. Waters},
  journal={Infection and immunity},
  year={2014},
  volume={82 7},
  pages={3002-14}
}
Vibrio cholerae is a Gram-negative bacterium that persists in aquatic reservoirs and causes the diarrheal disease cholera upon entry into a human host. V. cholerae employs the second messenger molecule 3',5'-cyclic diguanylic acid (c-di-GMP) to transition between these two distinct lifestyles. c-di-GMP is synthesized by diguanylate cyclase (DGC) enzymes and hydrolyzed by phosphodiesterase (PDE) enzymes. Bacteria typically encode many different DGCs and PDEs within their genomes. Presumably… CONTINUE READING
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