Bile acids: trying to understand their chemistry and biology with the hope of helping patients.

@article{Hofmann2009BileAT,
  title={Bile acids: trying to understand their chemistry and biology with the hope of helping patients.},
  author={Alan Frederick Hofmann},
  journal={Hepatology},
  year={2009},
  volume={49 5},
  pages={1403-18}
}
An informal review of the author's five decades of research on the chemistry and biology of bile acids in health and disease is presented. The review begins with a discussion of bile acid structure and its remarkable diversity in vertebrates. Methods for tagging bile acids with tritium for metabolic or transport studies are summarized. Bile acids solubilize polar lipids in mixed micelles; progress in elucidating the structure of the mixed micelle is discussed. Extensive studies on bile acid… CONTINUE READING