Bile acids: natural ligands for an orphan nuclear receptor.

@article{Parks1999BileAN,
  title={Bile acids: natural ligands for an orphan nuclear receptor.},
  author={Derek J. Parks and Steven G. Blanchard and Randy K. Bledsoe and Goutam Chandra and Thomas G. Consler and Steven A. Kliewer and Julie B. Stimmel and Timothy M Willson and Ann Marie Zavacki and David D. Moore and J{\"u}rgen M. Lehmann},
  journal={Science},
  year={1999},
  volume={284 5418},
  pages={1365-8}
}
Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological concentrations of free and conjugated chenodeoxycholic acid, lithocholic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclear receptor. As ligands, these bile acids and their conjugates modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1. These results provide… CONTINUE READING
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