Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.

@article{Glman2005BileAS,
  title={Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.},
  author={Cecilia G{\"a}lman and B Angelin and M Rudling},
  journal={Gastroenterology},
  year={2005},
  volume={129 5},
  pages={1445-53}
}
BACKGROUND & AIMS The conversion of cholesterol to bile acids by the liver is an important regulator of body cholesterol homeostasis. In rodents, both cholesterol and bile acid synthesis have marked diurnal rhythms that peak synchronously at midnight. The aim of this study was to establish whether such diurnal rhythms are also present in healthy humans. METHODS Serum levels of the markers 7alpha-hydroxy-4-cholesten-3-one (C4) monitoring bile acid biosynthesis and lathosterol reflecting… CONTINUE READING