Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.

@article{Fu2011BileAS,
  title={Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.},
  author={Dong Lai Fu and Yoshiyuki Wakabayashi and Jennifer Lippincott-Schwartz and Irwin M. Arias},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 4},
  pages={
          1403-8
        }
}
This study describes a unique function of taurocholate in bile canalicular formation involving signaling through a cAMP-Epac-MEK-Rap1-LKB1-AMPK pathway. In rat hepatocyte sandwich cultures, polarization was manifested by sequential progression of bile canaliculi from small structures to a fully branched network. Taurocholate accelerated canalicular network formation and concomitantly increased cAMP, which were prevented by adenyl cyclase inhibitor. The cAMP-dependent PKA inhibitor did not… CONTINUE READING

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