Bile acid receptors as targets for drug development

@article{Schaap2014BileAR,
  title={Bile acid receptors as targets for drug development},
  author={Frank G Schaap and Michael A. Trauner and Peter L. M. Jansen},
  journal={Nature Reviews Gastroenterology &Hepatology},
  year={2014},
  volume={11},
  pages={55-67}
}
The intracellular nuclear receptor farnesoid X receptor and the transmembrane G protein-coupled receptor TGR5 respond to bile acids by activating transcriptional networks and/or signalling cascades. These cascades affect the expression of a great number of target genes relevant for bile acid, cholesterol, lipid and carbohydrate metabolism, as well as genes involved in inflammation, fibrosis and carcinogenesis. Pregnane X receptor, vitamin D receptor and constitutive androstane receptor are… CONTINUE READING
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