Bile acid derived HMG-CoA reductase inhibitors.

@article{Kramer1994BileAD,
  title={Bile acid derived HMG-CoA reductase inhibitors.},
  author={Werner Kramer and G Wess and A Enhsen and Klaus Bock and Edvard Falk and Alexander Hoffmann and Georg Neckermann and Donald Gantz and Simone I Schulz and L Nickau},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1227 3},
  pages={137-54}
}
The target organ for HMG-CoA reductase inhibitors to decrease cholesterol biosynthesis in hypercholesterolemic patients is the liver. Since bile acids undergo an enterohepatic circulation showing a strict organotropism for the liver and the small intestine, the structural elements of an inhibitor for HMG-CoA reductase were combined with those for specific molecular recognition of a bile acid molecule for selective uptake by hepatocytes. Either, the HMG-CoA reductase inhibitors HR 780 and… CONTINUE READING