Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp.

@article{Li2009BileAD,
  title={Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp.},
  author={Huayue Li and Pramod Bapurao Shinde and Hye Ja Lee and Eun Sook Yoo and Chong-O Lee and Jongki Hong and Sang Ho Choi and Jee H Jung},
  journal={Archives of pharmacal research},
  year={2009},
  volume={32 6},
  pages={857-62}
}
In our search for bioactive metabolites from a marine sponge-associated bacterium Psychrobacter sp., a new bile acid derivative (1), which was assumed to be an artifact, were isolated along with six known (2-7) compounds by bioactivity-guided fractionation. Elucidation of the structure of the new compound was done using a combination of NMR ((1)H, (13)C, HMBC, HSQC, and COSY) and MS spectroscopy. Compound 1 exhibited moderate suppressive effects on both NO and IL-6 production at a concentration… CONTINUE READING

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