Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake.

@article{Baud2016BileDI,
  title={Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake.},
  author={Gr{\'e}gory Baud and Mehdi Daoudi and Thomas Hubert and Violeta Raverdy and M Pigeyre and Erik Hervieux and Magalie Devienne and Mohamed Ghunaim and Caroline K. Bonner and Audrey Quenon and Pascal Pigny and Andr{\'e} Klein and Julie Kerr-conte and Val{\'e}ry Gmyr and Robert J. Caiazzo and François Pattou},
  journal={Cell metabolism},
  year={2016},
  volume={23 3},
  pages={547-53}
}
Gastro-intestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, independent of weight loss. Although changes in intestinal bile trafficking have been shown to play a role, the underlying mechanisms are unclear. We performed RYGB in minipigs and showed that the intestinal uptake of ingested glucose is blunted in the bile-deprived alimentary limb (AL). Glucose uptake in the AL was restored by the addition of bile, and this effect was abolished when active glucose… CONTINUE READING