Bile Acids Activated Receptors Regulate Innate Immunity

  title={Bile Acids Activated Receptors Regulate Innate Immunity},
  author={S. Fiorucci and M. Biagioli and A. Zampella and E. Distrutti},
  journal={Frontiers in Immunology},
  • S. Fiorucci, M. Biagioli, +1 author E. Distrutti
  • Published 2018
  • Chemistry, Medicine
  • Frontiers in Immunology
  • Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, acting on several receptors including the G protein-coupled bile acid receptor 1 (GPBAR1 or Takeda G-protein receptor 5) and the Farnesoid-X-Receptor (FXR). Both receptors are placed at the interface of… CONTINUE READING
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