Bile Acids Activated Receptors Regulate Innate Immunity

@article{Fiorucci2018BileAA,
  title={Bile Acids Activated Receptors Regulate Innate Immunity},
  author={S. Fiorucci and M. Biagioli and A. Zampella and E. Distrutti},
  journal={Frontiers in Immunology},
  year={2018},
  volume={9}
}
  • S. Fiorucci, M. Biagioli, +1 author E. Distrutti
  • Published 2018
  • Chemistry, Medicine
  • Frontiers in Immunology
  • Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, acting on several receptors including the G protein-coupled bile acid receptor 1 (GPBAR1 or Takeda G-protein receptor 5) and the Farnesoid-X-Receptor (FXR). Both receptors are placed at the interface of… CONTINUE READING
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    References

    SHOWING 1-10 OF 128 REFERENCES
    Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders.
    • 180
    The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.
    • 253
    The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1
    • 341
    • PDF
    Reciprocal interactions between bile acids and gut microbiota in human liver diseases
    • T. Ikegami, A. Honda
    • Chemistry, Medicine
    • Hepatology research : the official journal of the Japan Society of Hepatology
    • 2018
    • 14
    Bile acids: regulation of synthesis
    • J. Chiang
    • Biology, Medicine
    • Journal of Lipid Research
    • 2009
    • 959
    • PDF
    The Role of the Gut Microbiota in Bile Acid Metabolism.
    • 32
    • PDF
    Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism.
    • 657
    • Highly Influential
    The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation
    • 55
    • PDF
    FXR activation inhibits inflammation and preserves the intestinal barrier in IBD
    • 20