Bile Acid Metabolism is an Intermediary Factor between Non-Alcoholic Steatohepatitis and Ischemic Heart Disease in SHRSP5/Dmcr Rats

  title={Bile Acid Metabolism is an Intermediary Factor between Non-Alcoholic Steatohepatitis and Ischemic Heart Disease in SHRSP5/Dmcr Rats},
  author={Shota Kumazaki and Mayumi Nakamura and S. Sasaki and Rina Tagashira and Nozomi Maruyama and Ikumi Sato and Shusei Yamamoto and Shang Ran and Shinichi Usui and Ryoko Shinohata and Takashi Ohtsuki and Satoshi Hirohata and Kazuya Kitamori and Mari Mori and Yukio Yamori and Shogo Watanabe},
  journal={Journal of Nutrition \& Food Sciences},
The non-alcoholic steatohepatitis (NASH) increases the cardiovascular risk regardless of risk factors in metabolic syndrome. The stroke-prone (SP) spontaneously hypertensive rats (SHRSP5/Dmcr), fed a high-fat and -cholesterol (HFC) diet and administered Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) presented NASH and cardiovascular disease. However, the intermediary factors between NASH and cardiovascular risk are still unknown. We investigated whether bile acids (BAs) play an… 
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