Bile Acid Metabolism in Extrahepatic Biliary Atresia (ehba): Lithocholic Acid in Stored Dried Blood Collected at Neonatal Screening

Abstract

Lithocholic acid (LCA) is a hepatotoxic compound. Fetal LCA might play a role in the pathogenesis of neonatal cholestasis/EHBA. Recent results show that fetal liver has capacity for hydroxylations of LCA (Ped. Res. 21:99, 1987).If the pathogenesis of EHBA involves increased fetal levels of LCA, the condition could be due to impaired fetal liver metabolism… (More)
DOI: 10.1203/00006450-199211000-00122

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