Bilayered Raman-intense gold nanostructures with hidden tags (BRIGHTs) for high-resolution bioimaging.

@article{Gandra2013BilayeredRG,
  title={Bilayered Raman-intense gold nanostructures with hidden tags (BRIGHTs) for high-resolution bioimaging.},
  author={Naveen Gandra and Srikanth Singamaneni},
  journal={Advanced materials},
  year={2013},
  volume={25 7},
  pages={1022-7}
}
Conventional SERS probes suffer from limited brightness and poor reproducibility and stability making them unsuitable for routine in vivo applications. A novel class of layered SERS probes is demonstrated in which individual nanostructures host electromagnetic hotspots, thus increasing brightness by more than two orders magnitude compared to conventional individual nanostructures. 
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