Bilayer measurement of endoplasmic reticulum Ca2+ channels.

  title={Bilayer measurement of endoplasmic reticulum Ca2+ channels.},
  author={Ilya B Bezprozvanny},
  journal={Cold Spring Harbor protocols},
  volume={2013 11}
Reconstitution of ion channels into planar lipid bilayers (also called black lipid membranes or BLM) is the most widely used method to conduct physiological studies of intracellular ion channels, including endoplasmic reticulum (ER) calcium (Ca(2+)) channels. The two main types of Ca(2+) release channels in the ER membrane are ryanodine receptors (RyanRs) and inositol(1,4,5)-trisphosphate receptors (InsP3Rs). Use of the BLM reconstitution technique enabled the initial description of the… CONTINUE READING

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