Bilateral subthalamic nucleus stimulation improves frontal cortex function in Parkinson's disease. An electrophysiological study of the contingent negative variation.

@article{Gerschlager1999BilateralSN,
  title={Bilateral subthalamic nucleus stimulation improves frontal cortex function in Parkinson's disease. An electrophysiological study of the contingent negative variation.},
  author={Willibald Gerschlager and François Alesch and Ross Cunnington and Lueder Deecke and Georg Dirnberger and W. Endl and G. Lindinger and Wilfried Lang},
  journal={Brain : a journal of neurology},
  year={1999},
  volume={122 ( Pt 12)},
  pages={2365-73}
}
Parkinson's disease involves impaired activation of frontal cortical areas, including the supplementary motor area and prefrontal cortex, resulting from impaired thalamocortical output of the basal ganglia. Electrophysiologically, such impaired cortical activation may be seen as a reduced amplitude of the contingent negative variation (CNV), a slow negative potential shift reflecting cognitive processes associated with the preparation and/or anticipation of a response. Surgical interventions… CONTINUE READING