Bilateral multicentric papillary renal tumors with heteroclonal origin based on tissue-specific karyotype instability.


BACKGROUND Papillary chromophilic renal tumors were cytogenetically characterized by combined trisomies 7 and 17 along with other numeric chromosome aberrations. They occurred as bilateral multifocal lesions. METHODS A patient was presented who simultaneously developed bilateral multicentric papillary renal tumors. Tissue specimens from six tumors and… (More)