Bilateral intranigral NMDA blockade increases status duration and neuronal injury from systemic kainic acid.

Abstract

Limbic seizures may be under the regulation of the substantia nigra, pars reticulata (SNpr). Using microinjection of the NMDA antagonist AP7, we investigated the role of SNpr in modulating seizures induced by kainic acid. Seizure severity was analyzed electrographically and neural injury assessed by measurement of heat shock protein (HSP) expression and… (More)

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