Bilateral hippocampal volume reduction in adults with post‐traumatic stress disorder: A meta‐analysis of structural MRI studies

  title={Bilateral hippocampal volume reduction in adults with post‐traumatic stress disorder: A meta‐analysis of structural MRI studies},
  author={Michael E. Smith},
Over the last decade a significant number of studies have reported smaller hippocampal volume in individuals with symptoms of post‐traumatic stress disorder (PTSD) relative to control groups, and in some cases hemispheric asymmetries in this effect have been noted. However these reported asymmetries have not been in a consistent direction, and other well‐controlled studies have failed to observe any hippocampal volume difference. This paper reports a systematic review and meta‐analysis of… 

Gender does not moderate hippocampal volume deficits in adults with posttraumatic stress disorder: A meta‐analysis

Hippocampal volumes were significantly smaller in the PTSD group compared to the control group, but gender did not significantly moderate any effect sizes in the meta‐regression or subgroup analyses, which suggests that hippocampal volume deficits in PTSD are independent of gender.

Does Hippocampal Volume in Patients with Posttraumatic Stress Disorder Vary by Trauma Type?

  • C. Hinojosa
  • Psychology, Biology
    Harvard review of psychiatry
  • 2022
Mixed-effects meta-analyses suggest that trauma type may moderate hippocampal volume in trauma-exposed individuals but not in those with PTSD.

Structural Magnetic Resonance Imaging Findings in Posttraumatic Stress Disorder and Their Response to Treatment: A Systematic Review

This review evaluates and categorizes the research of hippocampal volume reduction in patients with PTSD, and considers the response of the hippo- campus to pharmacological intervention.

Posttraumatic stress disorder symptom severity is associated with left hippocampal volume reduction: a meta-analytic study

An updated meta-analysis of hippocampal volume reductions associated with posttraumatic stress disorder (PTSD) shows that PTSD is associated with significant bilateral reduction of the hippocampus, consistent with the hypothesis that PTSD was more neurotoxic to the left hippocampus than to the right.

A meta-analysis of structural brain abnormalities in PTSD

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group

It is suggested that depression is a stronger predictor of hippocampal volumetry than PTSD, particularly in the CA1, and provide compelling evidence of more pronounced hippocampal phenotypes in comorbid PTSD and depression compared to either condition alone.



MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.

A smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory is consistent with high levels of cortisol associated with stress.

Lower hippocampal volume in patients suffering from depression: a meta-analysis.

A meta-analysis of studies that used magnetic resonance imaging to assess the volume of the hippocampus and related structures in patients with major depressive disorder found inclusion of the amygdala with the hippocampus appears to have decreased the likelihood of detecting volumetric differences in either structure.

Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD.

Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder.

Hippocampal volume and depression: a meta-analysis of MRI studies.

Hippocampal volume is reduced in patients with unipolar depression, maybe as a consequence of repeated periods of major depressive disorder.

Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization.

In female patients with BPD, the authors found reduction of the volumes of the hippocampus (and perhaps of the amygdala), but the association of volume reduction and traumatic experiences remains unclear.

Childhood trauma associated with smaller hippocampal volume in women with major depression.

A smaller hippocampal volume in adult women with major depressive disorder was observed exclusively in those who had a history of severe and prolonged physical and/or sexual abuse in childhood.

MRI Reveals Gross Structural Abnormalities in PTSD

To determine if patients with PTSD show MRI abnormalities beyond reduced hippocampal volumes, this study obtained magnetic resonance images from a large population of PTSD outpatients, using several different imaging protocols.