Bilateral globus pallidus stimulation for severe Tourette's syndrome: a double-blind, randomised crossover trial.

@article{Kefalopoulou2015BilateralGP,
  title={Bilateral globus pallidus stimulation for severe Tourette's syndrome: a double-blind, randomised crossover trial.},
  author={Zinovia Maria Kefalopoulou and Ludvic U. Zrinzo and Marjan Jahanshahi and Joseph Candelario and Catherine Milabo and Mazda Beigi and Harith Akram and Jonathan Hyam and Jennifer Clayton and Lewis Kass-Iliyya and Monty Silverdale and Julian Evans and Patricia Dowsey Limousin and Marwan I. Hariz and Eileen Maria Joyce and Thomas Foltynie},
  journal={The Lancet. Neurology},
  year={2015},
  volume={14 6},
  pages={595-605}
}
BACKGROUND Deep brain stimulation (DBS) has been proposed as a treatment option for severe Tourette's syndrome on the basis of findings from open-label series and small double-blind trials. We aimed to further assess the safety and efficacy of bilateral globus pallidus internus (GPi) DBS in patient's with severe Tourette's syndrome. METHODS In a randomised, double-blind, crossover trial, we recruited eligible patients (severe medically refractory Tourette's syndrome, age ≥20 years) from two… CONTINUE READING
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