Bilastine in allergic rhinoconjunctivitis and urticaria

@article{Bachert2010BilastineIA,
  title={Bilastine in allergic rhinoconjunctivitis and urticaria},
  author={Claus Bachert and Pavel Kuna and T Zuberbier},
  journal={Allergy},
  year={2010},
  volume={65}
}
To cite this article: Bachert C, Kuna P, Zuberbier T. Bilastine in allergic rhinoconjunctivitis and urticaria. Allergy 2010; 65 (Suppl. 93): 1–13. 

Bilastine in symptomatic allergic rhinoconjunctivitis and urticaria: a guide to its use

Bilastine has a favourable pharmacological profile, with a rapid onset of action and sustained efficacy over the 24-h dosing interval period, as well as a lack of CNS and cardiotoxic effects and clinically relevant drug interactions.

Up-dosing with bilastine results in improved effectiveness in cold contact urticaria

The effects of a standard 20 mg dose and up‐dosing to 40 and 80 mg of bilastine in reducing the symptoms of CCU and inflammatory mediator release following cold challenge are assessed.

Critical appraisal of bilastine for the treatment of allergic rhinoconjunctivitis and urticaria

During clinical development, bilastine was shown to be a drug that is adequately tolerated, with a similar effect to placebo with regard to drowsiness and changes in heart rate, and headaches were the most frequent adverse effect to be reported.

Effect of bilastine upon nasal obstruction.

The analysis of the data from the different clinical trials indicates that in patients with allergic rhinitis, the effect of bilastine upon nasal obstruction is superior to that of placebo and similar to those of other second-generation H1 antihistamines, manifesting within 24 hours after the start of treatment.

Bilastine: in allergic rhinitis and urticaria.

Bilastine was generally well tolerated, with a tolerability profile that was generally similar to that of the other second-generation antihistamines included in phase III clinical trials.

Chronic Urticaria

Current international guidelines recommend the use of non-sedating antihistamines as the first choice in therapy and up-dosing these up to fourfold in cases ofnon-response.

An overview of the novel H1-antihistamine bilastine in allergic rhinitis and urticaria

Clinical studies in allergic rhinitis and chronic urticaria show that once-daily treatment with bilastine 20 mg is effective in managing symptoms and improving patient’s quality of life, with at least comparable efficacy to other nonsedative H1-antihistamines.

Bilastine for the treatment of urticaria

Once-daily treatment with bilastine 20 mg is effective in managing symptoms and improving patient's quality of life in chronic urticaria, with at least comparable efficacy to levocetirizine.

Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review

Whether bilastine meets the criteria defined in the European Academy of Allergy and Clinical Immunology (EAACI)/ARIA proposals for oral H1-antihistamines for medications used in the treatment of allergic rhinitis is examined.

Safety and efficacy of bilastine: a new H1-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria

  • M. Church
  • Medicine
    Expert opinion on drug safety
  • 2011
Bilastine has high selectivity for H1-receptors, is rapidly and effectively absorbed, undergoes negligible metabolism and is a substrate for P-glycoprotein, which limits its passage across the blood–brain barrier.

References

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Background Bilastine is a new non‐sedative H1 receptor antagonist, indicated for the treatment of allergic rhinitis (AR) (seasonal and perennial).

Urticaria and infections

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EAACI/GA2LEN/EDF/WAO Guideline:Management of Urticaria

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Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi‐centre, double‐blind, randomized, placebo‐controlled study

To cite this article: Zuberbier T, Oanta A, Bogacka E, Medina I, Wesel F, Uhl P, Antépara I, Jáuregui I, Valiente R, the Bilastine International Working Group. Comparison of the efficacy and safety

The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber

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Pharmacologic and anti‐IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN)

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EAACI/GA2LEN/EDF guideline: management of urticaria

The recommended first line treatment are nonsedating H1 antihistamines, but dosages increased up to fourfold over the recommended doses may be necessary for different urticaria subtypes and in view of individual variation in the course of the disease and response to treatment.

The burden of rhinitis: nothing to sniff at.

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It is the little things in life that, when counted, start to add up — the service charge on banking transactions, the second glass of wine with dinner, the antihistamine taken for the stuffed-up nose.

Consensus statement * on the treatment of allergic rhinitis

Current guidelines emphasize the importance of an accurate diagnosis of patients presenting with rhinitis symptoms and the morbidity of SAR obviously depends on the geographic region, the pollen season of the plants, and the local climate.
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