Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

@article{Boyd1995BikAN,
  title={Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.},
  author={Janice M. Boyd and Gregory J. Gallo and Boobalan Elangovan and A B Houghton and Scott Malstrom and Brian J. Avery and Ronald G Ebb and Thirugnana Subramanian and Thomas D. Chittenden and Robert J. Lutz},
  journal={Oncogene},
  year={1995},
  volume={11 9},
  pages={
          1921-8
        }
}
The survival-promoting activity of the Bcl-2 family of proteins appears to be modulated by interactions between various cellular proteins. We have identified a novel cellular protein, Bik, that interacts with the cellular survival-promoting proteins, Bcl-2 and Bcl-xL, as well as the viral survival-promoting proteins, Epstein Barr virus-BHRF1 and adenovirus E1B-19 kDa. In transient transfection assays, Bik promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family… CONTINUE READING

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