Biguanide-atovaquone synergy against Plasmodium falciparum in vitro.

  title={Biguanide-atovaquone synergy against Plasmodium falciparum in vitro.},
  author={Kimberley Jones and Stephen A Ward},
  journal={Antimicrobial agents and chemotherapy},
  volume={46 8},
The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. All five biguanides tested interacted synergistically with atovaquone against Plasmodium falciparum in vitro. All of the other compounds tested were either additive or antagonistic. 
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