Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2.

@article{Song2012BiglycanIT,
  title={Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2.},
  author={Rui Song and Qingchun Zeng and Lihua Ao and Jessica A. Yu and Joseph C. Cleveland and Ke-Seng Zhao and David A. Fullerton and Xianzhong Meng},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 11},
  pages={
          2711-20
        }
}
  • Rui Song, Qingchun Zeng, +5 authors Xianzhong Meng
  • Published in
    Arteriosclerosis, thrombosis…
    2012
  • Medicine, Biology
  • OBJECTIVE Although biglycan (BGN) and oxidized low-density lipoprotein (oxLDL) accumulation has been observed in calcific, stenotic aortic valves, their role in the pathogenesis of calcific aortic valve disease is poorly understood. We hypothesized that soluble BGN induces the osteogenic response in human aortic valve interstitial cells via Toll-like receptor (TLR) 2 and TLR4 and mediates the proosteogenic effect of oxLDL. METHODS AND RESULTS Aortic valve interstitial cells of stenotic valves… CONTINUE READING

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